Amlodipine besilate

CAS:11470-99-6

Appearance White or almost white powder

Identification Meets the requirements

Specific Rotation -0.10 ~ +0.10°

Water ≤0.5%

Heavy metals ≤0.002%

Redidue in Ignition ≤0.2%

Related Substances Meets the requirements

Benzene Sulfonic Acid 27.3 ~ 28.7%

Ethanol ≤300ppm

Toluene ≤60ppm

Benzene ≤2ppm

Acetic Acid ≤600ppm

Methylamine ≤20ppm

Ethyl Benzene Sulfonate ≤5ppm

Particle Size Meets the requirements

Assay 98.0 ~102.0%

Standard USP33

Solubility:Slightly soluble in water; sparingly soluble in ethanol

Biological Activity:L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).

Usage:A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive

Introduction:                                  

Amlodipine is a medication used to treat high blood pressure andcoronary artery disease.While calcium channel blockers are not typically recommended in heart failure, amlodipine may be used if other medications are not sufficient for high blood pressure or heart related chest pain.Amlodipine is taken by mouth and has an effect for at least a day.

Amlodipine is a long acting calcium channel blocker of the dihydropyridine type. It works partly by increasing the size of arteries.

Amlodipine is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.It is available as a generic medication