Glibenclamide

Synonyms:LABOTEST-BB LT00244861;GLYBENCLAMIDE;GLYBENZCYCLAMIDE;GLYBURIDE;GIBENCLAMIDE;GLIBENCLAMIDE;5-CHLORO-N-[4-(CYCLOHEXYLUREIDOSULFONYL)PHENETHYL]-2-METHOXYBENZAMIDE;5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]-SULFONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE

CAS:10238-21-8

MF:C23H28ClN3O5S

MW:494

EINECS:233-570-6

Mol File:10238-21-8.mol

Molecular structure Glibenclamide Manufacturer, CAS No.:10238-21-8, Glibenclamide 99% Purity

Product Description:

Glibenclamide ( Glyburide )can increase liver glucose and glucose output by increasing the level of portal vein insulin or directly acting on the liver, inhibiting hepatic glycogenolysis and gluconeogenesis. The oral absorption is fast and the protein binding rate is very high at 95%. After oral administration, 2 to 5 hours of peak plasma concentration, sustained action for 24 hours. In the liver metabolism, liver and kidney from the discharge of about 50%.

Application:

1. Hypoglycemic drugs, for the treatment of mild, non insulin dependent diabetes mellitus

2. Glibenclamide and glibenclamide, glibenclamide, which belongs to the second generation oral sulfonylurea drugs, with the mechanism of toluene sulfonyl Ding Niao, its hypoglycemic effect was the strongest sulfonylurea, intensity for tolbutamide 200 ~ 250 times. Be selective effect on pancreatic beta cells, promote the secretion of insulin, can enhance the hypoglycemic effect of exogenous insulin, insulin receptor after strengthening effect. 

3. Glibenclamide is one of the drugs currently used to treat type 2 diabetes, the most often used, because the utility function is fast and strong, so after the application has obvious effect, can effectively control blood sugar, high blood sugar, is applicable to other sulfonylurea hypoglycemic effect not beautiful person.